Medical Jane: The Science of Medical Marijuana

Medical Jane: The Science of Medical Marijuana

Learn more about medical cannabis by reading our how-to articles, clinical studies, & more…

Source: The Science of Medical Marijuana



High Science, As the once-vilified drug becomes more accepted, researchers around the world are trying to understand how it works and how it might fight disease.

High Science, As the once-vilified drug becomes more accepted, researchers around the world are trying to understand how it works and how it might fight disease.

As the once-vilified drug becomes more accepted, researchers around the world are trying to understand how it works and how it might fight disease.

Source: High Science



Treating Cancer with Cannabis: The Science « Heavens 2 Betsey

Treating Cancer with Cannabis: The Science « Heavens 2 Betsey

While searching for information on the palliative affects of cannabis for chemotherapy patients, I came across an article describing a Cancer study from Spain which boasted remarkable results treating patients with cannabis. The results of the study showed reduction in tumor size and even complete cellular death in the tumors of patients who ingested concentrated THC. The claim sounds extraordinary but with a little research I was surprised by the amount of information I found supporting the treatment of cancer with concentrated cannabis.

The findings are clear: application of cannabinoids (such as THC and CBD) has the potential to slow the growth of Cancer cells, in many cases causing a reduction and even death in those tumor cells without harming the surrounding healthy tissue.

Cannabis doesn’t kill Cancer in the same way as chemotherapy treatment. With chemo everything dies. They flush the body with whichever brand of poison they’ve deemed the most effective, and the chemo attacks the cells in the body indiscriminately, cancerous and healthy alike. The patient’s job is simply to survive and outlive the cancer. There is no arguing that chemotherapy has shown to effectively kill cancer. But I think there is also little denying that it can greatly damage the body during the course of the treatment. Conversely, cannabis is not lethal and does not harm healthy cells.

There may be an initial period of adjustment during which patients can experience the side effects of excessive cannabis toxicity while building their tolerance to the oil, however once tolerance is achieved cannabis treatment comes with a long list of beneficial side effects such as lowered blood pressure, less depression and anxiety, better quality of sleep, and more.

With Cannabis treatment, patients ingest regular doses of highly concentrated oil (see blog by H2B President on Treating Cancer with Cannabis). Some choose to use it in conjunction with their current chemotherapy treatments, while others have turned to cannabis oil alone (usually coupled with a balanced diet and natural supplements). I won’t sit here and say that beyond a doubt Cannabis is the answer and cures all cancers. Truth is every cancer is different just like every person is different; and not all cancers (or people for that matter), react the same to treatment. Also depending on where the cancer is in relation to the cannabinoid receptors, the tumors might react to different types of cannabinoids (see our blog on cannabinoids and the endocannabinoid system).

It is important to note the patients coming forward with personal testimony showing their remarkable results: cancers declared inoperable, untreatable, or which didn’t react positively to conventional therapies showing successful treatment using cannabis oil. A growing number of cancer patients are turning to this therapy and the stories are finally beginning to emerge, though because of the varying legality and stigma surrounding this treatment, patients are hesitant to come forward and talk about their experiences. My grandmother, who found success using cannabis oil for her stage 4 breast cancer, has been met with doubt and criticism for her choice and for talking about it. It upsets me to think that though she found positive results, she can’t freely share this information with others.

I think the point here is if it is possible, if this might help someone, if it might give a cancer patient and their family their lives back, isn’t it important for it to be made known that it IS an option? With all the different types of chemotherapy doctors are willing to try out on patients, this nontoxic solution should also be available. Patients like my grandmother shouldn’t be afraid (or unable due to legal reasons) to seek out this medicine and they shouldn’t be met with criticism for sharing the success of their treatment with other cancer patients, family, and friends. We should all be sharing this information. The government needs to be allowing human clinical trials and pushing for more studies to be done. If we are trying to spread awareness and asking for more research to fight this terrible devastating disease, ISN’T IT ABOUT TIME WE TALK ABOUT CANNABIS?

Additional Blogs to Support Patients Considering this therapy:

Cannabis Therapy For The Treatment of Cancer
http://heavens2betsey.com/cannabis-therapy-for-the-treatment-of-cancer/

Understanding The Side Effects of Cannabis Toxicity
http://heavens2betsey.com/understanding-the-side-effects-of-cannabis-toxicity/

My Grandmothers Battle With Breast Cancer: A Success Story
http://heavens2betsey.com/spreading-awareness-through-research-not-selfies-my-grandmothers-battle-with-breast-cancer/

I have read a lot of research on cannabinoids and their potential as an effective Cancer treatment, and I encourage you to do the same. To get you started I am including links to the information I found; please read for yourself. There is a lot of out information out there. Don’t ignore this any longer. Spread awareness. Cannabis has the ability to fight Cancer. If you or someone you know has been touched by Cancer, now is the time to Share this information with them, before it is too late to try.

http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page4

 

http://www.cureyourowncancer.org/how-cannabis-oil-works.html

http://cannabinoidsociety.org/

http://www.cpmc.org/about/press/news2012/cannabis-brain.html

http://www.sciencedaily.com/releases/2007/04/070417193338.htm

http://www.collective-evolution.com/2013/08/23/20-medical-studies-that-prove-cannabis-can-cure-cancer/

 

http://scienceblog.cancerresearchuk.org/2012/07/25/cannabis-cannabinoids-and-cancer-the-evidence-so-far/

 

http://www.nature.com/bjc/journal/v95/n2/full/6603236a.html

http://www.ncbi.nlm.nih.gov/pubmed/22555283

 

http://www.cpmc.org/about/press/news2012/cannabis-brain.html

 

http://www.ncbi.nlm.nih.gov/m/pubmed/11269508/

http://m.jci.org/articles/view/37948

http://www.ncbi.nlm.nih.gov/m/pubmed/19425170/
http://m.mct.aacrjournals.org/content/6/1/173.long

 

http://m.jbc.org/content/282/28/20739.short

http://www.ncbi.nlm.nih.gov/m/pubmed/19704450/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774787/?hulpprogramma

Treating Cancer with Cannabis: The Science « Heavens 2 Betsey.

No Increased Risk Of Lung Cancer For Chronic Pot Smokers, According To New Study | Marijuana

No Increased Risk Of Lung Cancer For Chronic Pot Smokers, According To New Study | Marijuana

No Increased Risk Of Lung Cancer For Chronic Pot Smokers, According To New Study | Marijuana.

Alzheimer’s Caused By Loss of Cannabinoids, Study Shows – Leaf Science

Alzheimer’s Caused By Loss of Cannabinoids, Study Shows – Leaf Science

FACT: C-3, C-4 receptors in the Endo-Cannabinoid System wither away from lack of stimulation after a certain period of time. It’s too bad Ronald Reagan & others who suffered from Alzheimer’s were led to believe that they ought to wage a war against cannabis. Ironically, while Reagan was waging war against the herb, cannabinoid deficiency was literally killing him – as his mind deteriorated.

http://www.leafscience.com/2014/06/23/alzheimers-caused-loss-cannabinoids-study-shows/

Alzheimer’s Caused By Loss of Cannabinoids, Study Shows – Leaf Science.

Scientists Discover That Cannabis May Reduce Brain Damage Caused By Alcohol | Collective-Evolution

Scientists Discover That Cannabis May Reduce Brain Damage Caused By Alcohol | Collective-Evolution

Chemicals within cannabis have powerful antioxidant properties, and scientists believe this can protect the brain from damage. Too much alcohol can lead to permanent brain damage, among other things. A recent study from the University of Kentucky and the University of Maryland concluded that a chemical in marijuana called cannabidiol (CBD) could be used to prevent alcohol-induced brain damage. The study was published in September of 2013 in the journal Pharmacology Biochemistry and Behavior. (1)

The study outlines how excessive alcohol consumption results in neuro-degeneration as well as behavioral and cognitive impairments that are hypothesized to contribute to the chronic and relapsing nature of alcoholism. As a result they aimed to study the transdermal delivery of cannabidiol (CBD) for the treatment of alcohol-induced neuro-degeneration. At the conclusion of the study, results demonstrated the feasibility of using CBD transdermal delivery systems for the treatment of alcohol-induced neurodegeneration.(1)

Just like THC, CBD is another chemical found in marijuana, the difference is that it doesn’t get you ‘high.’ Both chemicals are strong antioxidants.

These results justify further preclinical development of transdermal CBD for the treatment of alcohol-induced neurodegeneration. It has been suggested that the neuroprotective effects of CBD observed during binge alcohol induced neurodegeneration are due to its high antioxidant capacity. (1)



The authors note that CBD acts as a stronger antioxidant than many well-known antioxidants. This new study was done on rat models, using both a skin patch and regular needle injection. Both methods produced similar magnitudes of neuroprotection, approximately 50 percent. Further studies need to be done here before human trials can begin. It’s surprising that human trials have yet to begin, it seems they should have began ages ago. Year after year we have credible published studies showing the clear link between cannabis and a healthy body environment.

The potential health benefits of cannabis are overwhelming, and potentially very threatening to the pharmaceutical industry. It is a shame that despite all of the evidence supporting the medicinal properties of this plant, it still has a negative connotation within the mainstream. Nobody can deny it’s medicinal benefits, and given the tremendous amount of information and research to support it, it seems pretty clear that this plant is a natural miracle.

Things seem to be changing, however. Last week, a European based pharmaceutical company called GW pharmaceuticals announced that they are set to commence its first ever phase of clinical trials for the treatment of brain cancer. You can read more about that here. A couple of months ago, I wrote an article presenting 20 medical studies that prove cannabis can cure cancer; I’ve presented them in this article (see below). If we want to stay on the topic of brain damage, dozens of studies have shown the potential benefits of cannabis on damaged brain tissue. A study published in the Journal of Clinical Investigation revealed that cannabinoids promote embryonic and adult hippocampus neurogenesis. (2) The list goes on and on, and it seems to be never-ending, especially when it comes to cannabis and the brain. If you would like to know more there is plenty of information that’s readily available.

Contrary to popular belief, smoking the Cannabis is not the most effective way in treating disease within the body as therapeutic levels cannot be reached through smoking. Creating oil from the plant or eating the plant is the best way to go about getting the necessary ingredients which are the Cannabinoids. Also, when Cannabis is heated and burnt it changes the chemical structure and acidity of the THC. This changes its ability to be therapeutic and anytime you burn something and inhale it, you create oxidation within the body which aids in free-radical production.

Humanity does not need to wait for a pharmaceutical company, or the medical industry to ‘OK’ its use for medicinal purposes. We constantly look towards these corporations for methods, approval and availability. This is something we can take into our own hands, the information is out there and if it’s something you feel can be of benefit you are free to try it. For medicinal use, it should be non-GMO, grown without pesticides and completely natural. In the hands of a pharmaceutical company, or future pill form, it might be hard to trust.

Below are links to more studies with regards to cancer and cannabis. (20 out of many more)
Brain Cancer

1. A study published in the British Journal of Cancer, conducted by the Department of Biochemistry and Molecular Biology at Complutense University in Madrid, this study determined that Tetrahydrocannabinol (THC) and other cannabinoids inhibit tumour growth. They were responsible for the first clinical study aimed at assessing cannabinoid antitumoral action. Cannabinoid delivery was safe and was achieved with zero psychoactive effects. THC was found to decrease tumour cells in two out of the nine patients.

2. A study published in The Journal of Neuroscience examined the biochemical events in both acute neuronal damage and in slowly progressive, neurodegenerative diseases. They conducted a magnetic resonance imaging study that looked at THC (the main active compound in marijuana) and found that it reduced neuronal injury in rats. The results of this study provide evidence that the cannabinoid system can serve to protect the brain against neurodegeneration.

3. A study published in The Journal of Pharmacology And Experimental Therapeutics already acknowledged the fact that cannabinoids have been shown to possess antitumor properties. This study examined the effect of cannabidiol (CBD, non psychoactive cannabinoid compound) on human glioma cell lines. The addition of cannabidiol led to a dramatic drop in the viability of glioma cells. Glioma is the word used to describe brain tumour. The study concluded that cannabidiol was able to produce a significant antitumor activity.

4. A study published in the journal Molecular Cancer Therapeutics outlines how brain tumours are highly resistant to current anticancer treatments, which makes it crucial to find new therapeutic strategies aimed at improving the poor prognosis of patients suffering from this disease. This study also demonstrated the reversal of tumour activity in Glioblastoma multiforme.
Breast Cancer

5. A study published in the US National Library of Medicine, conducted by the California Pacific Medical Centre determined that cannabidiol (CBD) inhibits human breast cancer cell proliferation and invasion. They also demonstrated that CBD significantly reduces tumour mass.

6. A study published in The Journal of Pharmacology and Experimental Therapeutics determined that THC as well as cannabidiol dramatically reduced breast cancer cell growth. They confirmed the potency and effectiveness of these compounds.

7. A study published in the Journal Molecular Cancer showed that THC reduced tumour growth and tumour numbers. They determined that cannabinoids inhibit cancer cell proliferation, induce cancer cell apoptosis and impair tumour angiogenesis (all good things). This study provides strong evidence for the use of cannabinoid based therapies for the management of breast cancer.

8. A study published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) determined that cannabinoids inhibit human breast cancer cell proliferation.
Lung Cancer

9. A study published in the journal Oncogene, by Harvard Medical Schools Experimental Medicine Department determined that THC inhibits epithelial growth factor induced lung cancer cell migration and more. They go on to state that THC should be explored as novel therapeutic molecules in controlling the growth and metastasis of certain lung cancers.

10. A study published by the US National Library of Medicine by the Institute of Toxicology and Pharmacology, from the Department of General Surgery in Germany determined that cannabinoids inhibit cancer cell invasion. Effects were confirmed in primary tumour cells from a lung cancer patient. Overall, data indicated that cannabinoids decrease cancer cell invasiveness.

11. A study published by the US National Library of Medicine, conducted by Harvard Medical School investigated the role of cannabinoid receptors in lung cancer cells. They determined its effectiveness and suggested that it should be used for treatment against lung cancer cells.
Prostate Cancer

12. A study published in the US National Library of Medicine illustrates a decrease in prostatic cancer cells by acting through cannabinoid receptors.

13. A study published in the US National Library of Medicine outlined multiple studies proving the effectiveness of cannabis on prostate cancer.

14. Another study published by the US National Library of Medicine determined that clinical testing of CBD against prostate carcinoma is a must. That cannabinoid receptor activation induces prostate carcinoma cell apoptosis. They determined that cannabidiol significantly inhibited cell viability.
Blood Cancer

15. A study published in the journal Molecular Pharmacology recently showed that cannabinoids induce growth inhibition and apoptosis in matle cell lymphoma. The study was supported by grants from the Swedish Cancer Society, The Swedish Research Council and the Cancer Society in Stockholm.

16. A study published in the International Journal of Cancer also determined and illustrated that cannabinoids exert antiproliferative and proapoptotic effects in various types of cancer and in mantle cell lymphoma.

17. A study published in the US National Library of Medicine conducted by the Department of Pharmacology and Toxicology by Virginia Commonwealth University determined that cannabinoids induce apoptosis in leukemia cells.
Oral Cancer

18. A study published by the US National Library of Medicine results show cannabinoids are potent inhibitors of cellular respiration and are toxic to highly malignant oral Tumours.
Liver Cancer

19. A study published by the US National Library of Medicine determined that that THC reduces the viability of human HCC cell lines (Human hepatocellular liver carcinoma cell line) and reduced the growth.
Pancreatic Cancer

20. A study published in The American Journal of Cancer determined that cannabinoid receptors are expressed in human pancreatic tumor cell lines and tumour biopsies at much higher levels than in normal pancreatic tissue. Results showed that cannabinoid administration induced apoptosis. They also reduced the growth of tumour cells, and inhibited the spreading of pancreatic tumour cells.

Sources:

(1) http://www.sciencedirect.com/science/article/pii/S0091305713002104

(2) http://www.jci.org/articles/view/25509

http://www.truthonpot.com/2013/09/12/marijuana-may-reduce-brain-damage-caused-by-alcohol-study/
Scientists Discover That Cannabis May Reduce Brain Damage Caused By Alcohol | Collective-Evolution.

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